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Publications

    Bullet Scientific Papers
  1. Demetriou, A. et al. Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver Failure. Annals of Surgery, Volume 239, Number 5, May 2004.
  2. Demetriou AA, Brown RS, Busuttil RW, Fair J, McGuire BM, Rosenthal P, Esch JMA, II, Lerut J, Nyberg SL, Salizzoni M, Fagan EA, de Hemptinne B, Broelsch CE, Muraca M, Salmeron JM, Rabkin JM, Metselaar HJ, Pratt D, De La Mata M, McChesney LP, Everson GT, Lavin PT, Stevens AC, Pitkin Z, Solomon BA. Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver Failure. Ann Surg 239: 660-670 (2004).
  3. Pazzi P, Morsiani E, Vilei MT, Granato A, Rozga J, Demetriou AA, Muraca M. Serum bile acids in patients with liver failure supported with a bioartificial liver. Aliment Pharmacol Ther 16: 1547-1554 (2002).
  4. Sugiyama N, Rozga J, Demetriou AA. Biological Extracorporeal Liver Assist Devices: A Mini-Review. Transplant Reviews 2001.
  5. Khalili TM, Navarro A, Ting P, Kamohara Y, Arkadopoulos N, Solomon B, Demetriou AA, Rozga J. Bioartificial liver treatment prolongs survival and lowers intracranial pressure in pigs with fulminant hepatic failure. Artif Organs 25: 566-570 (2001).
  6. Rozga J. Extracorporeal support of the failing liver. Med Sci Monitor 7(Suppl 1): 78-90 (2001).
  7. Hui T, Rozga J, Demetriou AA. Bioartificial liver support. J Hepatobiliary Pancreat Surg 2001; 8: 1-15.
  8. Ting P, Rozga J, Demetriou AA. Clinical Experience with Artificial Liver Support Systems. Can J Gastroenterol 14 Suppl. D: 79D - 84D (2000).
  9. Suk KS, Lilja H, Kamohara Y, Eguchi S, Arkadopoulos N, Neuman T, Demetriou AA, Rozga J. Bioartificial liver treatment in fulminant hepatic failure rats: effect on DNA binding activity of growth-induced and liver-enriched transcription factors. J. Surg. Res. 85: 243-250 (1999).
  10. Ting P, Suh K-S, Navarro A, Demetriou AA, Rozga J.Bioartificial liver lowers blood interleukin-10 and transforming growth factor b1. Surg. Forum 50, 7-8 (1999).
  11. Pitkin Z, Mullon C. Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system. Artif Organs 23: 829-833 (1999).
  12. Detry O, Ting P, Arkadopoulos N, Kahaku E, Watanabe F, Rozga J, Demetriou AA. Clinical use of a bioartificial liver in the treatment of acetaminophen-induced fulminant hepatic failure. Am. Surg. 65: 934-938 (1999).
  13. Arnaout W, Watanabe FD, Kahaku E, Navarro A, Ting P, Rozga J, Demetriou AA. Bioartificial liver support system for severe acute liver failure: summary of clinical experience. Organs Tissue 2:95-101 (1999).
  14. Rozga J, Demetriou AA. Clinical experience with a bioartificial liver.Med. Sc. Monitor 5(suppl.1): 165-171 (1999).
  15. Kamohara Y, Rozga J, Demetriou AA. Artificial Liver: Review and Cedars-Sinai experience. J. Hepatobiliary Pancreat. Surg. 5: 273-285 (1998).
  16. Arkadopoulos N, Detry O, Rozga J, Demetriou AA. Liver asssist systems: State of the Art. Int J Artif Organs 21: 119-125 (1998).
  17. Morsiani E, Pazzi P, Moscioni AD, Rozga J, Azzena G, Demetriou AA. In vitro Morphological and Functional Characterization of Isolated Porcine Hepatocytes for Extracorporeal Liver Support: Bile Acid Uptake and Conjugation. J Surg Res 79: 54-60 (1998).
  18. Demetriou AA. Support of trhe acutely failing liver: State of the Art. Ann Surg 228: 14-15 (1998).
  19. Chen SC, Mullon C J-P, Kahaku E, Watanabe F, Hewitt W, Eguchi S, Middleton Y, Arkadopoulos N, Rozga J, Solomon B, Demetriou AA. Treatment of severe liver failure with a bioartificial liver. Ann NY Acad Sci 831: 350-360 (1997).
  20. Watanabe F, Mullon C J-P, Hewitt WR, Arkadopoulos N, Kahaku E, Eguchi S, Khalili T, Arnaout W, Shackleton CR, Rozga J, Solomon B, Demetriou AA. Clinical Experience with a Bioartificial Liver (BAL) in the Treatment of Severe Liver Failure: A Phase I Clinical Trial. Ann. Surg. 5: 484-494 (1997).
  21. Chen SC, Hewitt WR, Rozga J, Watanabe F, Eguchi S, Kahaku E, Middleton Y, Demetriou AA. Clinical experience with a porcine hepatocyte-based liver support system. Int. J. Artif. Organs 19 (11): 664-669 (1996).
  22. Chen SC, Hewitt WR, Eguchi S, Watanabe F, Arkadopoulos N, Corno V, Suh KS, Middleton Y, Rodriguez O, Kahaku E, Lane RA, Demetriou AA, Rozga J. Prolonged survival in anhepatic pigs treated with a bioartificial liver. Surg. Forum 47: 161-163 (1996).
  23. Pazzi P, Morsiani E, Moscioni AD, Rozga J, Gullini S, Demetriou AA. Cholate handling by a bioartificial liver. It. J. Gastroenterol. 27 (suppl.1): 191-192 (1996).
  24. Chen S, Eguchi S, Watanabe F, Hewitt W, Kahaku E, Middleton Y, Arnaout W, Rozga J, Demetriou AA. Hepatic support strategies. Ð Transplant. Proc. 28:2036-2038 (1996).
  25. Rozga J, Demetriou AA. Artificial Liver: Evolution and Future Perspectives. - ASAIO Journal 41: 831-837 (1996).
  26. Kong LB, Chen S, Demetriou AA, Rozga J. Matrix-induced liver cell aggregates (MILCA) for bioartificial liver use. - Int. J. Artif. Organs 19: 43-49 (1996).
  27. Kamlot A, Rozga J, Watanabe FD, Demetriou AA. Review: Artificial Liver Support Systems. Ð Biotechnol. Bioeng. 50: 382-391 (1996).
  28. Morsiani E, Rozga J, Scott H, Lebow L, Moscioni AD, Kong L, McGrath M, Rosen H, Demetriou AA. Automated Liver Cell Processing Facilitates Large-Scale Isolation and Purification of Porcine Hepatocytes. ASAIO Journal 41:155-161 (1995).
  29. Morsiani E, Rozga J, Scott H.C., Kong L.B., Lebow L.T., McGrath M.F., Moscioni A.D., Demetriou A.A. Automated Large-Scale Production of Porcine Hepatocytes for Bioartificial Liver Support. Transplant. Proc. 26 (6): 4105-4106 (1994).
  30. Demetriou AA., Rozga J, Podesta L, LePage E, Morsiani E, Moscioni D, Hoffman A, McGrath M, Kong L, Rosen H, Villamil F, Woolf G,m Vierling J, Makowka L. Early Clinical Experience with a Hybrid Bioartificial Liver. Bioartificial Liver. Scand. J. Gastroenterol. 203 (30 suppl.), 111-117 (1995).
  31. LePage EB, Rozga J, Rosenthal P, Watanabe F, Scott HC, Talke AM, Demetriou AA. A Bioartificial Liver Used As A Bridge To Liver Transplantation in a 10 Year Old Boy. Am. J. Crit. Care Med., 3: 224-227 (1994).
  32. Rozga J, LePage EB, Moscioni AD, Podesta L, Villamil F, Hoffman A, Rosenthal P, Morsiani E, Makowka L, Demetriou AA. A Bioartificial Liver to Treat Severe Acute Liver Failure. Annals of Surgery, 219: 538-546 (1994).
  33. Rozga J, Moscioni D, Morsiani E, Demetriou AA. Isolated Hepatocytes in a Bioartificial Liver: A Single Group View and Experience. Biotechnology & Bioengineering, 54: 645-653 (1994).
  34. Rozga J, Podesta L, LePage E, Hoffman A, Morsiani E, Sher L, Woolf GM, Makowka L, Demetriou AA. Control of cerebral oedema by total hepatectomy and extracorporeal liver support in fulminant hepatic failure. Lancet, 342: 898-899 (1993).
  35. Rozga J, Williams RF, Moscioni AD, Giorgio T, Ro MS, Daniel Neuzil, Hakim R, Demetriou AA. Development of a bioartificial liver support system. Hepatology, 17: 258-264 (1993).
  36. Rozga J, Holzman MD, Ro MS, Griffin DW, Neuzil DF, Giorgio T, Moscioni AD, Demetriou AA. Hybrid Bioartificial Liver Support Treatment of Animals with Severe Ischemic Liver Failure. Ann. Surg., 217: 502-511 (1993).
  37. Georgio T, Moscioni AD, Rozga J, Demetriou AA. Mass Transfer in a Hollow Fiber Device Used as a Bioartificial Liver. Transactions ASAIO, 39: 886-892 (1993).
  38. Neuzil DF, Rozga J, Moscioni AD, Ro MS, Moscioni AD, Hakim R, Arnout WS, Demetriou AA. Use of a novel bioartificial liver in a patient with acute liver insufficiency. Surgery, 113: 340-343 (1993).
  39. Arnaout WS, Moscioni AD, Barbour RL, Demetriou AA. Development of a bioartificial liver: bilirubin conjugation in Gunn rats. J Surg Res 48: 379-382 (1990).
  40. Demetriou AA, Whiting J, Levenson AM, Chowdhury NR, Schechner R, Michalski S, Feldman D, Chowdhury JR. New method of hepatocyte transplantation and extracorporeal liver support. Ann Surg 204: 259-271 (1986).
    Bullet Book Chapters
  1. Pitkin Z, Switzer W, Chapman L. An interim analysis of PERV infectivity in 74 patients treated with a bioartificial liver in a prospective, randomized, multicenter controlled trial. Hepatology 34:249A (2001).
  2. Rozga J, Demetriou AA. Development and testing of a bioartificial liver. In: The Hepatocyte Review and Research. MN Berry & AM Edwards (eds.), Kulwer Academic Publishers, Netherlands, 2001, pp.1-15.
  3. Rozga J, Demetriou AA. Animal Models of Liver Failure. In: Surgical Research. WW Souba & DW Wilmore (eds), Academic Press, San Diego, CA, 2001, pp.623.-636.
  4. Rozga J, Demetriou AA. Support of the failing liver. In: Surgery of the Liver and Biliary Tract, Blumgart LH and Fong Y (eds), III edition, 2000, W.B.Saunders, London, UK.
  5. Support of the Acutely Failing Liver (2nd edition). Demetriou AA (ed). R.G. Landes Co., Biomedical Publishers Medical Intelligence Unit, TX, USA, 2000.
  6. Hewitt WR, Rozga J, Mullon CJP, Demetriou AA. Bioartificial liver: experimental and clinical experience. In: Ilots de Langerhans et hepatocytes. Vers une utilisation therapeutique. D Franco, K Boudjema, B Varet (eds). Les Editions INSERM; pp:105-118 (1998).
  7. Chen SC, Mullon C, Kahaku E, Watanabe F, Hewitt W, Eguchi S, Middleton Y, Arkadopoulos N, Rozga J, Solomon B, Demetriou AA. Treatment of Severe Liver Failure with a Bioartificial Liver. In: Bioartificial Organs: Science, Medicine and Technology. A.Prokop, D.Hunkeler and A.D.Cherrington (eds), The New York Academy of Sciences, vol.831, pp. 350-360 (1997).
  8. Pazzi P, Morsiani E, Muraca M, Vilei MT, Rozga J, Demetriou AA. Metabolic characterization of bioartificial liver: focus on bile production and excretion. In: "Bioartificial liver support systems - the critical issues." Eds.G.Crepaldi, A.A.Demetriou and M.Muraca. International Up To Date - 208, CIC Edizioni Internazionali, Via Lazzaro Spallanzani, 11-00161 Rome, Italy, pp.90-97 (1997).
  9. Rozga J, Lilja H, Suk Suh K, Eguchi S, Neuman T, Demetriou AA. A bioartificial liver: how does it work ? In: "Bioartificial liver support systems - the critical issues." Eds.G.Crepaldi, A.A.Demetriou and M.Muraca. International Up To Date - 208, CIC Edizioni Internazionali, Via Lazzaro Spallanzani, 11-00161 Rome, Italy, pp.98-103 (1997).
  10. Eguchi S, Chen SC, Rozga J, Demetriou AA. Tissue engineering: Liver. In: Yearbook of Cell and Tissue Transplantation. R.P.Lanza adn W.L.Chick (eds.), Kluwer Academic Publishers, Netherlands , pp.247-252, 1996/97.
  11. Rozga J, Demetriou AA. Artificial Liver Support. In: Liver Growth and Repair: From Basic Science to Clinical Practice (eds. A. Strain and A-M.Diehl). Chapman and Hall Ltd, 1997.
  12. Demetriou AA, Watanabe F, Rozga J. Artificial Hepatic Support Systems. In: Progress in Liver Diseases. JL Boyer, RK Ockner (eds.). W.B.Saunders Co., Philadelphia, vol.XIII., pp. 331-348, 1995.
  13. Support of the Acutely Failing Liver. Demetriou AA (ed). R.G. Landes Co., Biomedical Publishers Medical Intelligence Unit, TX, USA, 1994.
  14. Rozga J, Podesta L, Hoffman A, LePage E, Morsiani E, Moscioni AD, Demetriou AA. Development and Testing of a Bioartificial Liver. In: Internatinal Developments In Surgery And Surgical Research. Braverman MH and Tawes RL (eds.). Surgical Technology International II, San Francisco, CA, pp.215-218 (1993).
    Bullet PICM-19 Stem Cell Line
  1. Willard RR, Meekin, Talbot NC, Caperna TJ: Characterization of PICM-19H Porcine Liver Stem Cell Line for Potential Use in a Bioartificial Liver, 54th ASAIO Annual Conference, San Francisco CA, June 19-21, 2008
  2. Willard RR, Meekin JH, Peters GW, Baun MJ, Gerlach JC, Talbot NC, Caperna TJ: Maintenance of Hepatic Cell Function by the PICM-19H Porcine Liver Stem Cell Line Cultured in a Bioartificial Liver, 6th ISSCR Annual Meeting, Philadelphia PA, June 11-14, 2008
  3. Talbot NC, Blomberg le A, Mahmood A, Caperna TJ, Garrett WM: Isolation and characterization of porcine visceral endoderm cell lines derived from in vivo 11-day blastocysts, In Vitro Cell Dev Biol Anim. 2007 Feb;43(2):72-86
  4. Talbot NC, Caperna TJ, Wells KD.: The PICM-19 cell line as an in vitro model of liver bile ductules: effects of cAMP inducers, biopeptides and pH, Cells Tissues Organs. 2002;171(2-3):99-116
  5. Talbot NC, Caperna TJ, Lebow LT, Moscioni D, Pursel VG, Rexroad CE Jr.: Ultrastructure, enzymatic, and transport properties of the PICM-19 bipotent liver cell line, Exp Cell Res. 1996 May 25;225(1):22-34

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