HepaLife™ Announces Expansion of Exclusive License Agreement with U.S. Government Agency for Liver Cell Line

HepaLife’s expanded agreement with US Department of Agriculture allows for use of patented PICM-19 liver stem cell line as a malaria infection host system, in addition to artificial liver devices and in-vitro toxicological testing platforms.

Boston, MA – October 1st, 2008 – HepaLife Technologies, Inc. (OTCBB: HPLF) (FWB: HL1) (WKN: 500625) today announced that the Company has entered into an amendment of its worldwide, exclusive license agreement with the U.S. Department of Agriculture, Agricultural Research Service (USDA, ARS) for expanded use of the patented PICM-19 liver cell lines. The new agreement allows the Company to make use of the PICM-19 liver stem cells in artificial liver devices, in-vitro toxicological testing platforms, and the expanded field of use, “in-vitro infection host systems” for viral and protozoan agents such as malaria.

According to the Centers for Disease Control, each year 350–500 million cases of malaria occur worldwide, and over one million people die, most of them young children in sub-Saharan Africa. There is no effective vaccine to date.

The in-vitro infection host systems included in HepaLife’s expanded license agreement provide scientists with a cell-based technology to research and develop vaccines for infectious viruses and single-celled parasites (protozoan agents) such as Plasmodium falciparum, a species that causes malaria in humans. This specific infection is the most dangerous with the highest rates of complications and mortality, accounting for 80% of all human malaria infections and 90% of deaths.

The terms of the agreement cover specific patents and the PICM-19 hepatocyte cell lines. Financial details were not disclosed.

ABOUT HEPALIFE TECHNOLOGIES, INC.

Based in Boston, Massachusetts, HepaLife Technologies, Inc. (OTCBB: HPLF - News) (FWB: HL1) (WKN: 500625) is a developer of cell-based medical technologies addressing prevalent human health concerns.

Any statements contained in this press release regarding our ongoing research and development and the results attained by us to-date have not been evaluated by the Food and Drug Administration.

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