Pioneering Vaccine and Cell Culture Expert Joins HepaLife to Expedite Development of Avian Flu Vaccine

HepaLife’s patented PBS-1 cell line being developed for application in cell-culture based vaccine production to help protect against the spread of influenza viruses among humans, including potentially the high pathogenic H5N1 avian flu virus.

Boston, MA – January 16, 2007 – HepaLife Technologies, Inc. (OTCBB: HPLF) (FWB: HL1) (WKN: 500625) is pleased to announce the addition of Dr. Robert C. Tuttle to the Company’s Scientific Advisory Board.

With over 25 years of experience, Dr. Tuttle is widely regarded as an innovative, pioneering cell and tissue culture biologist, with extensive biopharmaceutical experience in cGMP pilot to commercial scale GMP culture, including three FDA approved human therapeutics and seven in clinical trials.

“In addition to his industry-wide experience, Dr. Tuttle’s unique blend of scientific know-how and commercial scale-up expertise in cell-cultures and vaccines are very helpful for us,” states Mr. Frank Menzler, President and CEO of HepaLife. “I welcome Dr. Tuttle to our expanding team and am eager to leverage his many years of experience as we integrate our PBS-1 cell line into a novel, cell-culture based vaccine production system to help protect against the spread of influenza viruses among humans, including potentially the high pathogenic H5N1 avian flu virus.”

Protected by five issued patents, including US patent 5,989,805 ("Immortal Avian Cell Line to Grow Avian and Animal Viruses to Produce Vaccines"), HepaLife is developing production methods to make flu vaccines faster, safer and at less cost by means of the Company’s patented PBS-1 line of cells.

HepaLife’s non-mammalian PBS-1 cell line is derived from an immortalized chicken embryo cell, and is being developed for more flexible cell-culture based vaccine production with the ability to quickly address prospective mutations in the avian influenza virus.

(View a CBS-affiliate, WWMT, television news story about HepaLife’s active cell-based vaccine research: www.hepalife.com/media)

Dr. Robert C. Tuttle

Dr. Robert C. Tuttle, Ph.D. currently serves as a Senior Executive Consultant for Boston Biotech Company LLC, providing expert analysis for the U.S. Department of Health and Human Services Bioshield therapeutics program and to the U.S. Department of Defense DARPA Accelerated Manufacturing Program (AMP) projects.

Prior to joining Boston Biotech, Dr. Tuttle served as Vice President Manufacturing for Genetix Pharmaceuticals, where he successfully led the cGMP manufacturing of the first clinical recombinant Lentivirus biologic for hemophilia gene therapy.

Between 2000 through 2004, Dr. Tuttle performed pioneering research in the Biodefense Medical Systems Department of the Battelle Memorial Institute. Among significant research achievements during his tenure at Batelle, Dr. Tuttle successfully invented and patented an avian coccidiosis vaccine, and further invented the production process for a new, better, safer recombinant anthrax protective vaccine.

Dr. Tuttle also served as the Director of Biologics for Novopharm Biotech between 1997 and 2000, during which time he invented processes to manufacture second entry biologics (Bio-Generics) such as TPA and EPO and a new, better formulation of paclitaxel (Taxol®) for first line cancer therapy. Taxol® is the first anti-cancer agent to surpass $500 million in US sales, and since FDA approval, has generated over $10 billion in revenues.

While at Immunomedics and Cytogen between 1991 and 1996, Dr. Tuttle scaled up and manufactured six of the first clinical monoclonal antibodies for in vivo colorectal, prostate and lymphoma cancer imaging and therapies. Earlier in his career, Dr. Tuttle directed manufacture and modernization of the commercial plasma proteins at CSL in Kankakee, Illinois, including the invention of the much-needed PCR-grade albumin, and scaled up the first FDA-approved tissue engineered living skin equivalent at Organogenesis in Cambridge, Massachusetts.

ABOUT HEPALIFE TECHNOLOGIES, INC.

HepaLife Technologies, Inc. (OTCBB: HPLF - News; FWB: HL1) (WKN: 500625) is a development stage biotechnology company focused on the identification, development and eventual commercialization of cell-based technologies and products.

Current cell-based technologies under development by HepaLife include 1) the first-of-its-kind artificial liver device, 2) proprietary in-vitro toxicology and pre-clinical drug testing platforms, and 3) cell-culture based vaccines to protect against the spread of influenza viruses among humans, including potentially the high pathogenic H5N1 virus.

For additional information, please visit www.hepalife.com

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