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Within 10 days after these initial symptoms develop jaundice, the urine becomes dark brown due to excretion of large amounts of bilirubin, cal - discolored and often bold in connection with the reduced supply of bile into the intestine. At this stage, patients usually go to the doctor that in 70% of an enlarged and slightly painful liver and in rare cases, splenomegaly. Jaundice is growing for a few days and then begins to decrease, disappearing completely after 2-8 weeks. In the blood are a minor transient anemia, lymphocytosis. Severe forms are accompanied by elongation of prothrombin time that does not change after the administration of vitamin K, severe, observed in acute viral hepatitis-B in the 1-2% of cases, characterized by a sudden sharp decrease in prothrombin index. Easy anicteric form of acute viral hepatitis may manifest only nonspecific symptoms of generalized infection: mild fever, general weakness, fatigue, nausea and vomiting, often the first symptom is a volatile dermal urticaria in children is possible papular acrodermatitis (small red rashes on the scalp, neck, hands and hips). In the course of acute viral hepatitis - in observed regular occurrence in the blood and disappearance from the blood markers of the virus - and its antigens produced by immune system antibodies to relevant antigens.